Can existing drugs reduce heat sensitivity in MS?

photo of Mark Baker

Lead researcher: Dr Mark Baker

Based at: Queen Mary, University of London

Grant we awarded: £108,020

Many people with MS find their symptoms get worse in the heat.
Heat sensitivity can have a huge impact on day to day activities, and right now we don’t have a treatment that can help to manage it.

What happens in the project?

We know changes in temperature can affect the way our nerves function, and make it more difficult from them to send messages. And Mark and his team have uncovered a potential mechanism for these changes.

They now want to test if two existing drugs, amiloride and bumetanide, can alter the temperature sensitivity of nerves in rodents.

How will it help people with MS?

We’re learning more about the biology behind heat sensitivity, bringing us closer to developing effective treatments to manage this symptom.e

The difference you can make

We want everyone with MS to have access to the treatments they need to live well with MS. With your help, we can continue to support vital research like this.

The next research breakthrough is in reach

Your donation will help stop MS.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette