Identifying new ways to repair myelin

Image of fluorescently tagged neurons

Dr Mark Kotter and Professor Shlomo Rotshenker

University of Cambridge & The Hebrew University of Jerusalem


About the project

MS is characterised by the immune system attacking the myelin coating of nerve cells in the brain and spinal cord. Identifying treatments that can help to repair myelin may help to prevent the progression of MS.

In an international collaboration between the UK and Israel, researchers are investigating new ways of repairing myelin and preventing nerve cell death. When myelin is damaged by the immune system, it creates a build-up of debris in the surrounding area that prevents the production of oligodendrocytes - the myelin-producing cells. This, in turn, prevents the repair of myelin. Researchers are looking at ways to clean up this debris, so that the oligodendrocytes are able to rebuild the damaged myelin and help to keep the nerve cells alive.

We are co-funding this project in partnership with the British Council, through their regenerative medicine initiative, BIRAX (Britain Israel Research and Academic Exchange Partnership).

How will it help people with MS?

Finding new ways to promote myelin repair in the laboratory is crucial in the development of treatments that can help people with MS.

The difference you can make

We urgently need treatments that can slow or stop the progression of disability in people with MS, and projects like this can help us get there

The next research breakthrough is in reach

Your donation will help stop MS.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette