7 things you need to know about HSCT
1. What is HSCT?
HSCT (sometimes referred to as AHSCT) is a procedure that aims to reset the faulty immune system. Haematopoietic stem cells are taken from your bone marrow or blood before your immune system is wiped out with chemotherapy. The cells are then reintroduced into your blood, where they grow a new immune system that will hopefully no longer attack your nerves.
2. Who can benefit from HSCT?
HSCT tackles the immune system – as do all existing disease modifying therapies (DMTs). So we tend to see the best results in those whose MS symptoms are being caused by inflammation and immune attacks (shown by relapses or on an MRI).
Studies have found that HSCT is most effective for people who have highly active relapsing MS. That means they're experiencing relapses despite taking one of the more effective DMTs available. It can also help some people with early progressive MS, if they're still experiencing active inflammation.
3. How effective is HSCT for MS?
HSCT has proven to be very effective for people with highly active MS. It can reduce relapses and stabilise or even improve disability for some. But HSCT can’t regrow nerves or repair damaged myelin. So it can’t help those with advanced progressive MS who are no longer having relapses and don’t shown signs of inflammation on an MRI .
4. What are the risks of HSCT?
According to a European register, one or two in every 100 people (1.3%) having HSCT in clinical trials have died as a result of the treatment. But since 2005, the mortality rate has dropped to around 1 in 330 (0.3%). Chemotherapy can cause hair loss, fever, nausea and infertility. Your risk of infections in the future also increases. If you already have a lot of nerve damage, as in progressive MS, the chemotherapy can do more harm than good.
5. Where can I get HSCT?
HSCT is available on the NHS at limited sites across the UK, but not as a first line treatment You'll need to be referred by your neurologist or GP. If you're considering getting HSCT outside of the NHS we recommend you check out the credentials of any centre offering the treatment. In Europe such clinics should have JACIE accreditation.
6. Will HSCT become available more widely for MS?
The current eligibility criteria are based on clinical trials that show HSCT can stop active inflammation. But because it's a very intensive treatment it's unlikely to be offered to people whose MS is being controlled by drug DMTs, which come with fewer risks.
Clinical trials of HSCT for advanced MS have not been as successful. This is likely because the worsening of disability results from damage to or loss of nerve cells, rather than through immune attacks.
7. What stem cell treatments are there for MS?
HSCT is the only proven stem cell treatment for MS. Other forms of experimental stem cell therapy should only be offered as part of a regulated clinical trial.
Researchers hope that mesenchymal stem cell therapy could help modify the immune system and potentially boost myelin repair. The procedure is currently being tested in phase 2 clinical trials that are investigating whether it's safe and how long any benefits might last.