Does early treatment with alemtuzumab prevent progression?

Image shows a hospital drip

Lead researcher: Professor Alasdair Coles

Based at: University of Cambridge

MS Society funding: £92,613

Status: Active

About the project

Currently there is no consensus on how best to analyse the effectiveness of MS therapies in the long-term. This exciting research will allow for effective assessment of long-term data from people with MS who have been treated with alemtuzumab. The aim is to provide researchers across the globe with access to data from 1991-present, so we can identify the best way of measuring effectiveness of certain treatments.

This will help to answer the question ‘does early treatment with disease modifying drugs improve the prognosis for people with MS?’

Results so far

Alasdair’s team has shown, for the first time, that disease-modifying therapies (DMTs) can delay the development of secondary progressive MS. This happens when people with relapsing MS are treated within 5 years of when their first symptoms occur.

This is the first time that the effect of drugs on the transition from relapsing MS to secondary progressive MS has been analysed. The researchers will continue to monitor and assess people who have been or are currently being treated with alemtuzumab, to add to the growing bank of evidence.

How will it help people with MS?

This research is providing people with MS with the information they need to be able to make informed decisions about their treatment. This can help people to weigh up the effectiveness of a treatment against the potential side effects.

Gaining information about the effectiveness of early intensive treatments in relation to transitioning to progressive MS, gives people with MS better certainty about how their condition may progress.

The difference you can make?

Helping to fund research like this will enable people with MS to have the opportunity to make informed decisions about their treatment and give greater certainty about their future.

The next research breakthrough is in reach

Your donation will help stop MS.

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    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette