High dose simvastatin treatment for secondary progressive MS

Photograph of an unnamed researcher at their laboratory workstation

Professor John Greenwood

University College London

£314,179

About the project

Researchers have revealed potential benefits of high dose simvastatin for people with secondary progressive MS. People taking 80 mg/day of simvastatin had reduced brain atrophy (shrinkage) and better end of study disability scores in a phase 2 clinical trial.

This research highlights the potential of simvastatin as a treatment. But right now we don't fully understand how statins are working in MS.

Our researchers will use advanced imaging techniques to investigate what effects simvastatin is having in the brains of people with secondary progressive MS. They're particularly interested in changes in blood flow in the brain, as well as brain cell abnormalities.

How will it help people with MS?

Right now there are no treatments for progressive MS. And this is largely because we don’t understand enough about what causes it.

Our researchers want to find out what's happening in secondary progressive MS in more detail. This will help us to understand the benefits of simvastatin treatment, as well as giving us an opportunity to develop new treatments for progressive MS.

The difference you can make

Your money could help fund research into finding the answers we need to develop treatments for progressive MS.

Make a donation to help stop MS

The next research breakthrough is in reach. Your donation will help stop MS.

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£10could buy vital lab supplies for MS researchers, helping them find ways to stop MS faster

£20could pay for lab equipment like petri dishes to grow bacteria important for studying the genetics of MS

£30could process one blood sample, giving us crucial information about genes that could lead to treatment breakthroughs

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

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