High dose simvastatin treatment for secondary progressive MS

Photo: Close up of researcher using a pippette

Professor John Greenwood

University College London


About the project

Researchers have revealed potential benefits of high dose simvastatin for people with secondary progressive MS. People taking 80 mg/day of simvastatin had reduced brain atrophy (shrinkage) and better end of study disability scores in a phase 2 clinical trial.

This research highlights the potential of simvastatin as a treatment. But right now we don't fully understand how statins are working in MS.

Our researchers will use advanced imaging techniques to investigate what effects simvastatin is having in the brains of people with secondary progressive MS. They're particularly interested in changes in blood flow in the brain, as well as brain cell abnormalities.

How will it help people with MS?

Right now there are no treatments for progressive MS. And this is largely because we don’t understand enough about what causes it.

Our researchers want to find out what's happening in secondary progressive MS in more detail. This will help us to understand the benefits of simvastatin treatment, as well as giving us an opportunity to develop new treatments for progressive MS.

The difference you can make

Your money could help fund research into finding the answers we need to develop treatments for progressive MS.

You can read about the phase 3 trial to test if simvastatin could become a treatment for secondary progressive MS by clicking this here.

The next research breakthrough is in reach

Your donation will help stop MS.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette