Could simvastatin be a treatment for secondary progressive MS?
Lead researcher: Professor Jeremy Chataway
Based at: UCL Institute of Neurology
Co-funded by: NIHR, UCL, NHS, National MS Society and us.
MS Society funding: £1.17 million
In this video, Professor Jeremy Chataway talks about the MS STAT-2 trial and how it could help people with MS.
The MS-STAT2 trial will test if simvastatin can slow disability progression over a three-year period. They will measure progression using the Expanded Disability Status Scale, which assesses changes in walking and other MS symptoms.
What happens in the trial?
The trial began in summer 2017 and will involve 1,180 people with secondary progressive MS. It will take six years to complete and involve over 30 trial centres across the UK.
Recruitment for MS-STAT2 is now open across the UK until the end of 2020. If you'd like to be considered to take part in the trial, you can register your interest on the UCL website.
How will it help people with MS?
Right now there are no treatments that can slow or stop the accumulation of disability associated with MS. If this trial is successful, simvastatin could be one of the first treatments licensed for secondary progressive MS.
The difference you can make
The race is on to find therapies that will slow progression. You can help speed up the process by supporting projects like this.
The next research breakthrough is in reach
Your donation will help stop MS.
£30could process one blood sample, giving researchers crucial information about genes and the immune system.
£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.
£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.
Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.
£10a month could pay for lab equipment like microscope slides to study the building blocks of MS
£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics
£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks
Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.