Could simvastatin be a treatment for secondary progressive MS?

Dr Jeremy Chataway

UCL Institute of Neurology

£3.82M in partnership with NIHR and National MS Society.

Additional support from UCL and the NHS

In this video, Dr Jeremy Chataway talks about the MS STAT-2 trial and how it could help people with MS.

> Help fund MS research

About the project

We’re proud to be co-funding the phase 3 trial testing if simvastatin can slow progression in secondary progressive MS. If successful, simvastatin could be of the first treatments licensed for this type of MS.

The MS-STAT2 trial will test if simvastatin can slow disability progression over a three-year period. They will measure progression using the Expanded Disability Status Scale, which assesses changes in walking and other MS symptoms.

The trial began in summer 2017 and will involve 1,180 people with secondary progressive MS. It will take six years to complete and involve over 30 trial centres across the UK.

We expect recruitment for the trial to open in late summer 2018. We'll update this page when recruitment begins.

If you'd like to register your interest for the trial, please contact our Research team at If you've already registered your interest, we'll be in touch when recruitment opens.

How will it help people with MS?

Right now there are no treatments that can slow or stop the accumulation of disability associated with MS. If this trial is successful, simvastatin could be one of the first treatments licensed for secondary progressive MS.

The difference you can make

The race is on to find therapies that will slow progression. You can help speed up the process by supporting projects like this.

Make a donation to help stop MS

The next research breakthrough is in reach. Your donation will help stop MS.

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£10could buy vital lab supplies for MS researchers, helping them find ways to stop MS faster

£20could pay for lab equipment like petri dishes to grow bacteria important for studying the genetics of MS

£30could process one blood sample, giving us crucial information about genes that could lead to treatment breakthroughs

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

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