A moment that changed MS research - 20 years ago
The MS Society Tissue Bank is born
Professor Reynolds explains: “MS is a condition that only affects the human brain and spinal cord. I realised we could only answer many of the important questions we were asking by studying the actual tissue damaged by MS.”
He approached the MS Society with a proposal to set up a national tissue bank, where people with MS could donate their brain and spinal cord after their death to be used for research.
Excited by what this could mean for MS science, we’ve been supporting his work ever since.
Understanding tissue changes in MS
Professor Reynolds saw that advances being made in understanding MS in the blood and immune system were not being matched for the central nervous system.
MRI scans show damage to the brain, but don’t tell you anything about chemical or cellular changes happening due to MS.
A new look at MS
People who choose to donate their tissue after they die are changing the way we study MS. “It’s the ultimate gift that allows us to study just about any area of MS,” said Professor Reynolds.
So far, over 780 people have donated their brain and spinal cord, with more than 4,600 others registered. These include people with and without MS.
But more are needed, as the team at Imperial College is sending out tissue to researchers every day. “To advance our understanding of progression, we really need people with highly active progressive MS to register,” said Professor Reynolds.
Supporting MS research around the world
Tens of thousands of samples have been sent all over the world. They have contributed to hundreds of groundbreaking research papers, including a dozen in the last year alone.
Researchers use tissue samples to study MS genetics, develop diagnostic tests, find new molecules responsible for damaging our nerves and identify drug targets, as well as substituting animal experiments.
“Without tissue, a lot of this research simply cannot be done,” said Professor Reynolds.
The MS Society Tissue Bank has come a long way since 1998. It now operates jointly with the Parkinson’s UK Brain Bank, reducing running costs for both charities.
Dr Susan Kohlhaas, Director for Research at the MS Society, said: “The MS Society Tissue Bank makes an enormous contribution to MS research around the world, and we’re immensely proud to have funded it from its inception. Of course, none of it would have been possible without our amazing supporters, for which we’re so grateful.”
The next research breakthrough is in reach
Your donation will help stop MS.
£30could process one blood sample, giving researchers crucial information about genes and the immune system.
£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.
£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.
Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.
£10a month could pay for lab equipment like microscope slides to study the building blocks of MS
£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics
£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks
Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.