Siponimod recommended for secondary progressive MS
The Committee for Medicinal Products for Human Use has recommended siponimod is approved as a treatment for people with active secondary progressive MS.
Siponimod (brand name Mayzent) is taken as a daily tablet.
What does this decision mean?
This is an exciting step forward for MS treatment. It means the drug is very likely to be licensed by the European Medicines Agency very soon.
When will siponimod be available?
The next step is for UK health bodies to decide whether siponimod should be available on the NHS. We’ll be working hard to make sure that happens as soon as possible. But the process can take some time, and we don't expect a decision until the middle of 2020.
NICE is in the early stages of considering siponimod for use in England and Wales already.
We expect the Scottish Medicines Consortium and Department of Health in Northern Ireland to carry out similar assessments too.
Who can get siponimod?
Siponimod hasn't been recommended for everyone with secondary progressive MS. It's only been recommended for people who have evidence of inflammatory activity on an MRI scan and/or still have relapses.
There may be further restrictions like how long you've had MS for, and level of your disability. We won’t know these in full until the license is published. Find out more about secondary progressive MS
What’s the evidence?
Research found siponimod can reduce the risk of disability progression by 21% compared with a placebo. Siponimod also significantly reduced the rate of brain atrophy (shrinkage) and the number of relapses people experienced.
Read more about the science behind siponimod
'An important first step’
Genevieve Edwards, our Director of External Affairs, said: “This exciting step forward means siponimod could become the first oral DMT licensed for active secondary progressive MS. The drug provides a much needed option for people with secondary progressive MS to take control of their condition. Once licensed, the next challenge is making sure siponimod is available on the NHS to everyone who could benefit.
“Because siponimod only works on the immune system it won’t help everyone with secondary progressive MS – just those still experiencing relapses. We can see a future where nobody needs to worry about their MS getting worse, but we need drugs that repair myelin and protect the nerves from damage. Through our Stop MS Appeal, we hope to raise £100 million to find treatments for everyone with MS.”
The next research breakthrough is in reach
Your donation will help stop MS.
£30could process one blood sample, giving researchers crucial information about genes and the immune system.
£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.
£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.
Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.
£10a month could pay for lab equipment like microscope slides to study the building blocks of MS
£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics
£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks
Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.