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Ozanimod (Zeposia)

Ozanimod is a treatment for 'active' relapsing MS. Its brand name is Zeposia.

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Who can take ozanimod?

In Scotland you can have ozanimod if:

  • you have ‘active’ relapsing MS. That means you’ve had a recent relapse and/or MRI scans show that you have new lesions. On top of that, a drug that comes as a tablet should be suitable for you, or that’s the type of drug you’ve asked for

Ozanimod isn’t available on the NHS at the moment in England, Wales and Northern Ireland. A final decision on whether it will be is expected sometime in 2021.

How does ozanimod work?

Special types of cells in your immune system, called T and B cells, are thought to cause a lot of the damage in MS. They normally kill viruses and bacteria that get into your body but in MS they damage your nerves. Ozanimod stops them leaving your lymph nodes where they're made. This means fewer of them get into your brain and spinal cord where they would attack the covering (myelin) around your nerves.

Ozanimod is a tablet you take once a day.

How well does ozanimod work?

Two trials have compared ozanimod to beta interferon, a drug already used to treat MS. Ozanimod was significantly better than beta interferon at reducing how many relapses people got and how many lesions were seen on their MRI scans.

Relapses dropped by: 38% compared to beta interferon

This means that in a trial over two years, on average, people saw a 38% drop in the number of relapses they had. This was compared to people who took a beta interferon.

When it comes to disability getting worse, it’s not yet clear how much ozanimod can slow this down. 

What are the side effects of ozanimod?

The most common ozanimod side effects include colds, headaches, as well as chest and urinary tract infections. Compared to other DMTs the risk of side effects, especially serious ones, is somewhere in the middle and similar to those you get with fingolimod. That said, in trials ozanimod had fewer side effects than fingolimod.

When you take your first dose of the drug, it can cause your heart beat to slow down (it soon goes back to normal). Because of this, your first dose will be smaller, then it’s gradually increased over the first week.

Ozanimod causes a short-lived rise in your liver enzymes. They generally go back to normal levels without you needing to stop taking it.