Targeting node of Ranvier dysfunction in multiple sclerosis
In MS, the immune system mistakenly attacks the protective myelin coating around nerves in the brain and spinal cord. Myelin works like insulation around electrical wires, helping nerve signals travel quickly and efficiently.
Nerve fibres have tiny gaps in their myelin coating called ‘nodes of Ranvier’. These act like signal boosters to keep electrical messages moving smoothly along the nerve. In healthy brains, these nodes can change and regulate how fast signals travel down nerves.
About the project
Recent research suggests that in MS, these nodes can stop working properly, even before any myelin is lost. This could play a key role in MS progression.
In this project, Dr Jonathan Lezmy will investigate how these early changes at the nodes disrupt nerve signaling and contribute to MS progression. He will also test whether drugs could potentially be used to improve node function and boost nerve signals.
Jonathan will study what happens to nerve signals and node structure before and after myelin damage in mice with an MS-like condition. He will then test a group of drugs that target proteins at or near the nodes. And may help improve their function. Some of these are already in use for other conditions. Jonathan will then test whether these drugs can also improve how the nodes of Ranvier work in human brain tissue donated during routine neurosurgical operations.
How will it help people with MS?
This research will deepen our understanding of what happens in the brain in MS and could open new paths for treatment. It could identify drugs that improve node function. This could help to protect nerve signals, support remyelination, and potentially slow MS progression.
This research could also reveal new ways to spot MS early by looking for early signs of node problems before it’s possible to see signs of myelin damage.
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