To stop MS, we need to protect our nerves from permanent damage.
How are nerves damaged in MS?
In MS, nerve cells can be damaged when their protective myelin covering is attacked. The loss of myelin leaves the nerve fibre underneath vulnerable. So it can be damaged by things like myelin debris left behind after the attack, or by other toxic substances.
We think nerve damage can happen early on in the condition, even where there is still some intact myelin.
Why is protecting nerves important in MS?
Once a nerve dies, it cannot be replaced. With the nerve fibres lost, the messages can no longer get through. This can lead to disability becoming permanent.
Nerve cell death is a natural part of ageing for everyone. But for people with MS, this happens at a faster rate, because more cells are being lost. You can see this on MRI scans, with our brains shrinking over time.
To stop MS, it's vital we find treatments that can protect nerves from damage.
How can we protect nerves in MS?
The aim of neuroprotection is simple – to keep nerve cells happy, healthy and alive.
Researchers have identified a number of different ways to help us protect nerves:
Keeping the power on
Nerve cells use a lot of energy. This is generated by tiny powerhouses spread throughout the cell called mitochondria. Scientists have found that mitochondria are damaged in MS, meaning nerves don’t get the energy they need, stop working properly and eventually die.
Our researchers are working hard to unravel more of the mysteries of mitochondria. Once we understand what goes wrong with mitochondria in progressive MS, we can start developing therapies to fix it.
Creating a healthy environment
Healthy cells require healthy surroundings. We know that when myelin is damaged, debris and toxins build up around the nerves, causing inflammation.
Researchers are looking at ways to encourage the brain to clear this debris, creating a healthy environment for nerves.
Nerve cell transport
Inside every nerve there's a network of super highways that allow important molecules to go where they're needed.
Research suggests that in MS this transport system goes wrong, with traffic jams stopping the nerve working properly.
Our research into protecting nerves
We’re investing in some exciting research to help protect nerves in MS.
MS Society Tissue Bank
Our tissue bank supports scientists around the world who are working to understand nerve damage in MS. It enables researchers to investigate what actually happens in the human brain and spinal cord in MS, and to identify new treatment targets.
In 2017 we announced we’re co-funding a phase 3 trial to test if simvastatin can slow progression in secondary progressive MS. Simvastatin is commonly used to treat high cholesterol, but research suggests that it reduce inflammation and could protect nerves from damage.
The next research breakthrough is in reach
Your donation will help stop MS.
£30could process one blood sample, giving researchers crucial information about genes and the immune system.
£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.
£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.
Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.
£10a month could help cover the cost of a MS Helpline call with our specialist MS Nurse
£20a month could help people with MS get vital support from our Benefits Advisor
£30a month for a year could pay for a day on the MS Helpline, helping people in our MS community
Your regular donation means we can be there for everyone with MS. So no one has to face this pandemic alone.