Modelling the human choroid plexus in progressive MS
The choroid plexus (ChP) is a structure found in the brain’s waterways that has many important roles. It makes cerebrospinal fluid (CSF), a clear fluid that surrounds the brain and spinal cord, providing cushioning, supplying nutrients and removing waste. It acts as a barrier between the blood and the CSF, protecting the brain from harmful substances. And it can also regulate inflammation, circadian rhythm and cognition.
Researchers have found that the ChP is enlarged in people with progressive MS. This was linked to an increase in inflammatory factors in the CSF. The size of the ChP has also been linked to the severity of progressive MS. Although these patterns have been identified, we still need to better understand the role of the ChP in progressive MS.
About the project
In this project, Alexandra and the team aim to understand whether there are biological differences between the ChPs of healthy people and those with progressive MS. They believe that the cells that make up the ChP behave differently in people with progressive MS. This leads to a weaker barrier between the blood and the CSF, more inflammation, and more damage to neurons, ultimately causing disability.
The team will generate mini ChPs in a dish from stem cells taken from both people with progressive MS and healthy people. They’ll investigate whether and how the cells in these mini ChPs might contribute to inflammation and weaker barriers in people with progressive MS.
How will it help people with MS?
This work will help to explain the biology of the ChP in people with progressive MS. By understanding how the ChP changes during MS progression, it may be possible to develop targeted therapies.
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