Discovering the key factors driving progression using a large UK MS Society Tissue Bank population   

Recent results from Owain’s lab suggest that neuron loss is the strongest predictor of MS progression. But we don’t have accurate tests to measure nerve damage happening in the brain. This makes it hard to decide which treatments should be used and when they should be given. 

About the project   

When nerve cells die, the molecules that make up these cells are released into the cerebrospinal fluid (CSF). This is the fluid that surrounds the brain and spinal cord. This PhD project aims to identify specific molecules in the CSF that are linked to nerve damage. To achieve this, the researcher will: 

1. Measure the extent of nerve cell damage and inflammation in over 300 brains that have been donated to the MS Society Tissue Bank. They will study thin slices of brain tissue under the microscope to measure any damage. 
2. Test CSF samples from the same donors to measure which molecules are present at which levels and match them to the damage seen in the brain tissue. 
3. Test whether any of the molecules that are linked with nerve damage can also be found in blood samples. If the marker is present in the blood then it can be quickly and easily tested in clinical settings without the need for a lumbar puncture procedure. 

How will it help people with MS?   

Any molecules that are found in both the CSF and blood that are linked with nerve damage will then be taken forward for further testing. This research could lead to the development of a blood test to predict who might be at risk of progression and more severe MS.  

This information would help people with MS and their doctors to make informed choices about their treatment plans. It could also help to identify appropriate participants for clinical trials and track their responses to treatments.