Comparing treatment effectiveness and safety in HSCT, Lemtrada and Ocrevus

Image shows a hospital drip

Lead researcher: Dr Sharmilee Gnanapavan

Based at: University College London

Our funding: £39,473

Status: Active

About the project

Haematopoietic stem cell transplantation (HSCT) is an intense chemotherapy treatment that can be used to treat MS. Current evidence suggests that HSCT can reduce relapses and improve the quality of life of some people living with MS. But we don’t know yet how it compares to existing treatments in terms of safety and effectiveness. A Phase 3 clinical trial (STAR-MS) is comparing HSCT to alemtuzumab and ocrelizumab in people with relapsing MS. 

Current highly effective DMTs can reduce nerve cell death. But the use of chemotherapy in HSCT means it might cause damage to nerve cells. In this add-on study to STAR-MS, researchers will compare neurofilaments (a marker of nerve damage in MS) in people taking alemtuzumab and ocrelizumab and those who have HSCT. 

How will it help people with MS?

Knowing more about the safety and effectiveness of different treatments will allow people with MS to make more informed choices about their treatment.

The difference you can make

Helping to fund research like this will allow people with MS to make informed decisions about their treatment, and give greater certainty about their future.

The next research breakthrough is in reach

Your donation will help stop MS.

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    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette