Clinical trial to test the safety and potential of stem cells for the treatment of MS

Headshot of Dr Paolo Muraro, an MS researcher testing the safety and potential of stem cells for the treatment of MS

Lead researcher: Dr Paolo Muraro

Based at: Imperial College

Grant we awarded: £525,474

Mesenchymal stem cells (MSCs) are found in many parts of the body and are usually taken from bone marrow, skin and fat tissue.

We have some evidence to suggest they may help promote myelin repair and have a positive effect on the immune system.

What happens in the project?

Our researchers are exploring the safety and potential benefits of mesenchymal stem cell therapy in a small clinical trial. The phase 2 trial will involve 15 people with highly active MS who have evidence of inflammation on an MRI scan. All 15 people will have mesenchymal stem cell therapy, with half undergoing the treatment immediately. The other half will have the treatment six months later.

Paolo and his team are testing if the therapy can reduce numbers of lesions as measured by MRI. Safety and side effects will also be monitored.

This research is part of an international trial called MESEMS, which will involve around 150 people with MS.

How will it help people with MS?

This research will help to reveal the potential of mesenchymal stem cell therapy for people with MS.

The difference you can make

Scientists believe that there is now enough evidence to suggest that stem cells hold real potential for the treatment of MS.

By donating to MS research you will be part of an international concerted effort in stem cell research.

The next research breakthrough is in reach

Your donation will help stop MS.

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    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

MS researcher at work in lab, using a pipette