Can bexarotene boost myelin repair in MS?

Headshot of Professor Alasdair Coles, an MS researcher, looking at the camera.

Lead researcher: Professor Alasdair Coles

Based in: University of Cambridge

Grant we awarded: £251,210

To stop MS we need to find treatments that repair the damage to the protective myelin coating around nerves.

This phase 2 trial will test if a drug called bexarotene can help the brain regenerate myelin in people with MS.

Infographic introducing the Bexarotene Trial

What happens in this project?

It will involve 50 people with relapsing MS who are taking a disease modifying therapy (DMT).

Bexarotene is already used to treat some types of cancer. And researchers at our centres in Cambridge and Edinburgh discovered that the drug might help people with MS. Together they showed that a protein in the brain targeted by bexoratene encourages myelin repair.

> Read more about the trial

How will it help people with MS?

Right now there are no treatments that can boost myelin repair in MS. This trial will help us to understand if bexoratene has potential as an MS treatment.

The difference you can make

The race is on to find therapies that will slow progression. You can help speed up the process by supporting projects like this.

The next research breakthrough is in reach

Your donation will help stop MS.

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£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

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MS researcher at work in lab, using a pipette