Can bexarotene boost myelin repair in MS?

Headshot of Professor Alasdair Coles, an MS researcher, looking at the camera.

Professor Alasdair Coles

University of Cambridge

£251,210

About the project

To stop MS we need to find treatments that repair the damage to the protective myelin coating around nerves.

This phase 2 trial will test if a drug called bexarotene can help the brain regenerate myelin in people with MS. It will involve 50 people with relapsing MS who are taking a disease modifying therapy (DMT).

Bexarotene is already used to treat some types of cancer. And researchers at our centres in Cambridge and Edinburgh discovered that the drug might help people with MS. Together they showed that a protein in the brain targeted by bexoratene encourages myelin repair.

> Read more information about the trial

How will it help people with MS?

Right now there are no treatments that can boost myelin repair in MS. This trial will help us to understand if bexoratene has potential as an MS treatment.

The difference you can make

The race is on to find therapies that will slow progression. You can help speed up the process by supporting projects like this.

Make a donation to help stop MS

The next research breakthrough is in reach. Your donation will help stop MS.

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£10could buy vital lab supplies for MS researchers, helping them find ways to stop MS faster

£20could pay for lab equipment like petri dishes to grow bacteria important for studying the genetics of MS

£30could process one blood sample, giving us crucial information about genes that could lead to treatment breakthroughs

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

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