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Research projects

Type of MS

Type of MS
Advanced MS
Clinically isolated syndrome (CIS)
Primary progressive MS
Secondary progressive MS
Relapsing MS

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Research area
Immunomodulation
Genes
Infection
Myelin repair
Neuroprotection
Stem cells
Vitamin D

Research focus

Research focus
Care and services
Cause and prevention
Symptom management
Treatment and therapies

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Doctoral Training Centre in symptom management: using digital health therapeutics to treat MS symptoms

The Doctoral Training Centre at King’s College London will focus on how we can use digital health interventions to treat MS symptoms.

Doctoral Training Centre in symptom management: physical activity for symptom and disease management in MS

The Doctoral Training Centre at Glasgow Caledonian University focuses on exercise and physical activity for people with moderate to severe MS.

How can an online programme work best to help people with MS stay in work?

Optimising access to vocational rehabilitation services for people with MS through MS charities

How does progressive MS compare to other neurological conditions?

Characterising molecular features of neurodegeneration in progressive multiple sclerosis

Can a protein involved in inflammation benefit myelin repair?

Investigating NLRP3 and inflammasomes as targets for MS treatments

How can the Mas receptor affect myelin repair?

Understanding the role of the Mas receptor when myelin is lost in conditions like MS

Could a local social media hub help newly diagnosed people manage their MS?

A locally-tailored social media hub for MS self-management in newly diagnosed people living with MS

DELIVER-MS Extension: comparing initial treatment approaches

DELIVER-MS stands for: Determining the Effectiveness of earLy Intensive Versus Escalation approaches for Relapsing-remitting Multiple Sclerosis

Does a protein called survivin reduce myelin production?

Researchers think a protein called survivin might work against our natural ability to repair myelin.

Using MRI to investigate the mechanisms of sodium build-up in MS

Sodium plays a number of key roles in the body. The sodium levels in our brain are very tightly regulated. But in MS the levels can be elevated. And this increase in sodium is connected to higher levels of disability and progressive forms of MS.

Risk factors for conditions of the heart and blood vessels in people with MS

People with MS have a higher risk of heart and blood vessel conditions compared to people that don’t have MS. But we don’t yet know what risk factors contribute to someone with MS being more likely to have these conditions.

How does a “molecular motor” affect risk and progression of MS?

Recently, a gene called KIF21B was linked to increased susceptibility to MS. This project will help to understand the role KIF21B plays in MS risk and in MS progression.

The eye as a window to brain inflammation in MS

There’s a type of inflammation called compartmentalised inflammation. Researchers now want to test if compartmentalised inflammation also develops in the back of the eye, called the retina.

Could changes in DNA during pregnancy affect MS relapses?

People with MS who become pregnant sometimes experience fewer relapses, and researchers don’t yet understand why. By understanding how pregnancy can sometimes lead to a reduction in relapses for people with MS, researchers can better understand why an immune attack happens.

Can special proteins promote myelin repair in MS?

If we can repair myelin in the brain and spinal cord, we might be able to slow or stop MS progression. But there are currently no licensed treatments that can boost myelin repair.

Can myelin repair be improved by controlling one molecule?

In MS, some immune cells mistakenly attack myelin around nerve cells, which causes inflammation and leaves nerves vulnerable to damage. But, some immune cells are involved in decreasing inflammation and some in myelin repair. New treatments could encourage these beneficial cells, but we need to understand much more about the process involved.

REFUEL-MS: Can a digital intervention help to improve fatigue in people with MS?

Data from the UK MS Register shows 90% of people with MS experience fatigue. But less than a third of people have been offered treatment for their fatigue as part of their routine care.

COMPASS-MS: a therapist-supported digital treatment for distress in MS

Many people with MS experience psychological distress, depression and anxiety. This project aims to develop a digital programme to treat distress in MS.

Which DMTs cross the placenta during pregnancy?

Women with MS who become pregnant may be advised to stop taking some disease modifying therapies (DMTs). Because we don’t yet know exactly what the impact is of all DMTs on babies in the womb. So it’s important we carry out research to understand which medications are more or less likely to cause problems.

Developing PET imaging to identify types of MS lesions

Professor Franklin Aigbirhio hopes advanced imaging technology could to help identify which treatments could work in different people.

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