Neuroprotective strategies: Amiloride Clinical Trial in Optic Neuritis (ACTION)

Image shows research test tubes stacked up

Dr Matthew Craner

University of Oxford


About the project

The aim of this project is to investigate the effect of amiloride as a new therapy for protecting nerves from damage following inflammation. Amiloride is a drug already used to treat heart failure and high blood pressure, so we know it's safe. The study will use imaging techniques to look at the effect of amiloride on nerve fibre loss in the retina of people following optic neuritis.

How will it help people with MS?

Effective therapies for protecting nerve fibres from damage in MS are urgently needed. It is also important to find ways of quickly assessing these therapies. This project could develop amiloride as a neuroprotective therapy for MS. The findings of this project will also pave the way for more clinical trials in the future.

The difference you can make

Projects like this are vital if we are to achieve our goal of developing and testing neuroprotective therapies that prevent and slow disability progression.

The next research breakthrough is in reach

Your donation will help stop MS.

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£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette