Is ROS a good drug target for myelin repair?

Test tube and lab equipment

Lead researcher: Dr Mark Kotter

Based at: University of Cambridge

MS Society funding: £296,617

Status: Active

About the project

In MS, the protective myelin coating around nerve cells is damaged. Myelin-producing cells, called oligodendrocytes, are needed to repair the damage. But in MS, they don’t always form when and where they're needed, or produce myelin at the right time.

Mark’s team have shown that special chemicals known as reactive oxygen species (or ROS) are important in stimulating oligodendrocytes to produce new myelin. In this project the researchers will evaluate ROS as a potential drug target for treating MS. The team will also investigate how ROS is able to promote myelin repair, hopefully identifying new pathways for treatment development.

How will it help people with MS?

Finding treatments that will slow and stop MS is our top research priority. To help everyone with MS, especially people with progressive forms of the condition, we need treatments that boost the natural process of myelin repair in the brain and spinal cord.

The difference you can make

We want everyone with MS to have access to the treatments they need to live well with MS. With your help, we can continue to support vital research like this.

The next research breakthrough is in reach

Your donation will help stop MS.

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    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette