Questions about MS? Call us on 0808 800 8000

Investigating how FoxO3a functions in remyelination

Cure scientist
Lead researcher:
Dr Mark Kotter
Based at:
University of Cambridge
MS Society funding:

About the project

In MS, damage to the myelin sheath leaves nerve cells exposed and vulnerable to injury. There are specialised cells made in the brain and spinal cord that produce myelin. These cells are called oligodendrocytes and in MS, far fewer are produced therefore reducing the capacity of the body to repair myelin. Progress has been made in understanding how oligodendrocytes are produced, and one key protein identified is called FoxO3a. Researchers have found that by blocking FoxO3a activity they can cause more oligodendrocytes and myelin to be made. This project will further investigate what FoxO3a does in the body, and how this might be modulated to promote myelin production.

How will it help people with MS?

A better understanding of the role of FoxO3a in oligodendrocyte production could help us to learn more about how to promote remyelination and stop MS from getting worse. This study could help to identify targets that could be used for new remyelination therapies.

The difference you can make

The MS Society has been funding research since 1956. To help us to continue funding world-class MS research projects like this, donate to research.

Urgent appeal: Help us be there for everyone with MS

Urgent appeal: Help us be there for everyone with MS

Donate now
Donation type