Identifying whether exercise-related symptoms can predict MS progression

Person in medical centre taking part in a phyiso session

Lead researcher: Dr Don Mahad

Based at: University of Edinburgh

Our funding: £39,418

Status: Active

About the project

Exercise offers a number of benefits to people with MS, but often brings on temporary symptoms like foot drop (a difficulty lifting up the front of your foot). This can limit your ability to walk without stopping and resting. People with MS often report this kind of exercise-related symptom early on in the condition, and for many it gets worse over time. This happens even when they aren’t experiencing relapses.

The researchers will measure how exercise-related symptoms change over time in people with MS who run and walk regularly but aren’t currently experiencing relapses. They'll compare these changes to other measures of how severe someone’s MS is – like the Extended Disability Status Scale.

How will it help people with MS?

At the moment, we don't have a test to confidently identify people with MS who are developing progressive MS silently (without obvious signs like new MRI lesions). In the long term, these researchers want to find out whether the change in exercise-related symptoms over time can help them predict who has MS that is silently progressing.

The difference you can make 

MS is unpredictable and can be different for everyone. Your support will help to fund research to identify people who are progressing silently, and make sure people with MS are receiving the right care and treatment. 

The next research breakthrough is in reach

Your donation will help stop MS.

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    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette