Does fractalkine coordinate myelin repair in MS?

Image shows myelin making cells

Dr Anna Williams

University of Edinburgh

£253,523

About the project

In MS, the protective myelin coating around nerve cells is damaged. Helping the body repair myelin is one of the most promising areas of research to develop new treatments for all forms of MS.

We've already discovered a number of molecules that promote myelin repair. But to develop the most effective treatments we need to identify those controlling the overall process. Research has highlighted a molecule called fractalkine, which may coordinate myelin repair.

Our researchers will discover if fractalkine plays a critical role in myelin repair using samples provided by our Tissue Bank. They will also test whether targeting fractalkine can promote remyelination in a mouse model of MS.

How will it help people with MS?

If we can show that fractalkine plays an important role in the remyelination process then we can look for drugs that control its presence in the brain. This is therefore the first step in developing an important new treatment that could benefit everyone living with MS.

The difference you can make

There are currently no strategies to slow progression in MS. Supporting research like this helps to bring us closer to reaching this goal.

Make a donation to help stop MS

The next research breakthrough is in reach. Your donation will help stop MS.

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£10could buy vital lab supplies for MS researchers, helping them find ways to stop MS faster

£20could pay for lab equipment like petri dishes to grow bacteria important for studying the genetics of MS

£30could process one blood sample, giving us crucial information about genes that could lead to treatment breakthroughs

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

Young girl in hospital ward talking to male nurse