Can we find drugs that remove myelin debris more quickly?
Lead researcher: Dr David Lyons
Based at: University of Edinburgh
MS Society funding: £39,710
About the project
In MS, the immune system damages the protective myelin coating around nerve cells. In order for the brain to repair the damage with new myelin, it first has to get rid of the old myelin debris. Special immune cells called macrophages usually clear up the debris, but in MS they struggle to do so quickly enough.
David’s team recently developed a live imaging system to automatically assess how different drugs affect myelin formation in growing zebrafish.
This project will use the same system to look at how myelin debris is cleared in the brains of zebrafish. By looking at the effect of different drugs on the rate of clean-up the team aim to identify ones that have the potential to be tested as myelin repair treatments for MS.
How will it help people with MS?
Finding treatments to slow or stop progression in MS is our top priority. Developing ways to quickly identify drugs that could help the brain repair damaged myelin is an important step towards developing new treatments.
The next research breakthrough is in reach
Your donation will help stop MS.
£30could process one blood sample, giving researchers crucial information about genes and the immune system.
£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.
£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.
Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.
£10a month could pay for lab equipment like microscope slides to study the building blocks of MS
£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics
£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks
Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.