Can we find drugs that remove myelin debris more quickly?

fish-research

Lead researcher: Dr David Lyons

Based at: University of Edinburgh

MS Society funding: £39,710

Status: Active

About the project

In MS, the immune system damages the protective myelin coating around nerve cells. In order for the brain to repair the damage with new myelin, it first has to get rid of the old myelin debris. Special immune cells called macrophages usually clear up the debris, but in MS they struggle to do so quickly enough.

David’s team recently developed a live imaging system to automatically assess how different drugs affect myelin formation in growing zebrafish.

This project will use the same system to look at how myelin debris is cleared in the brains of zebrafish. By looking at the effect of different drugs on the rate of clean-up the team aim to identify ones that have the potential to be tested as myelin repair treatments for MS.

How will it help people with MS?

Finding treatments to slow or stop progression in MS is our top priority. Developing ways to quickly identify drugs that could help the brain repair damaged myelin is an important step towards developing new treatments.

The next research breakthrough is in reach

Your donation will help stop MS.

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£10could buy vital lab supplies for MS researchers, helping them find ways to stop MS faster

£20could pay for lab equipment like petri dishes to grow bacteria important for studying the genetics of MS

£30could process one blood sample, giving us crucial information about genes that could lead to treatment breakthroughs

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

Photo: young girl with MS sits in hospital chair smiling at male nurse