Can three existing drugs protect nerves from damage in MS?

Image shows Dr Jeremy Chataway from the UCL Institute of Neurology

Lead researcher: Dr Jeremy Chataway

Based at: UCL Institute of Neurology

Funded by an MRC and NIHR partnership, and us.

We contributed: £300,000.

We’re proud to co-fund this innovative phase 2 trial, testing three potential treatments for secondary progressive MS.

The trial will run for three years and test the benefits of amiloride, fluoxetine and riluzole against a placebo. All three drugs are already used to treat other conditions.

What happens in the project?

MS-SMART will involve 440 people with secondary progressive MS. Our researchers will use MRI scans to test if any of the drugs could protect nerves from damage in MS. They will do this by measuring if the drugs slow the rate of brain atrophy (shrinkage).

The trial is due to finish in 2018.

How will it help people with MS?

Right now there are no treatments that can slow or stop the accumulation of disability in secondary progressive MS. This trial will help to identify promising drugs that can be tested in phase 3 trials.

The difference you can make

The race is on to find therapies that will slow progression. You can help speed up the process by supporting projects like this.

The next research breakthrough is in reach

Your donation will help stop MS.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£10could buy vital lab supplies for MS researchers, helping them find ways to stop MS faster

£20could pay for lab equipment like petri dishes to grow bacteria important for studying the genetics of MS

£30could process one blood sample, giving us crucial information about genes that could lead to treatment breakthroughs

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

Photo: young girl with MS sits in hospital chair smiling at male nurse