Can three existing drugs protect nerves from damage in MS?

Image shows Dr Jeremy Chataway from the UCL Institute of Neurology

Dr Jeremy Chataway

UCL Institute of Neurology

Funded by an MRC and NIHR partnership, and the MS Society.

We contributed £300,000.

About the project

We’re proud to be co-funding this innovative phase 2 trial, which will test three potential treatments for secondary progressive MS.

The trial will run for three years and test the benefits of amiloride, fluoxetine and riluzole against a placebo. All three drugs are already used to treat other conditions.

MS-SMART will involve 440 people with secondary progressive MS. Our researchers will use MRI scans to test if any of the drugs could protect nerves from damage in MS. They will do this by measuring if the drugs slow the rate of brain atrophy (shrinkage).

The trial is due to finish in 2018.

How will it help people with MS?

Right now there are no treatments that can slow or stop the accumulation of disability in secondary progressive MS. This trial will help to identify promising drugs that can be tested in phase 3 trials.

The difference you can make

The race is on to find therapies that will slow progression. You can help speed up the process by supporting projects like this.

Make a donation to help stop MS

The next research breakthrough is in reach. Your donation will help stop MS.

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£10could buy vital lab supplies for MS researchers, helping them find ways to stop MS faster

£20could pay for lab equipment like petri dishes to grow bacteria important for studying the genetics of MS

£30could process one blood sample, giving us crucial information about genes that could lead to treatment breakthroughs

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

Young girl in hospital ward talking to male nurse