Can restoring oxygen to the central nervous system help in MS

Photo of microscope

Lead researcher: Professor Ken Smith

Based at: Institute of Neurology, UCL

Grant we awarded: £222,716

About the project

Researchers have shown that inflammation in MS can reduce blood flow to the brain and spinal cord, resulting in less oxygen reaching the cells.

As well as stopping the nerve cells from working properly, a lack of oxygen also damages the myelin-making cells in the brain, and this can cause myelin damage.

Our researchers want to know if improving blood flow could be beneficial in MS. They will use three different models of MS to look for drugs that can restore the blood supply to the brain even when there’s inflammation, meaning the cells get enough oxygen to function properly.

The team will look at which of these drugs is most effective at reducing MS symptoms and promoting myelin health.

How will it help people with MS?

If successful, this project could identify a drug treatment that can treat functional and structural damage in MS by restoring oxygen levels. Such a treatment could then be taken forward to clinical trial.

The difference you can make

We want everyone with MS to have access to effective treatments. With your help, we can continue to support vital research like this.

The next research breakthrough is in reach

Your donation will help stop MS.

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    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

  • Please enter an amount

    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette