Can cerebrospinal KIF levels predict MS progression?

image shows nerve cell fibres

Lead researcher: Dr Alastair Wilkins

Based at: University of Bristol

Grant we awarded: £39,984

Reducing the uncertainty around MS progression is one of our top research priorities.

We know that worsening symptoms and MS progression is linked to the nerve damage, but right now this is difficult to measure.

What happens in the project?

Our researchers want to develop a new way of measuring nerve damage. They'll do this by measuring the levels of certain proteins called KIF in the fluid surrounding the spinal cord and brain. They will also try and identify genetic changes that increase the likelihood of nerve damage using blood samples.

If they are successful, we could use this information to predict how someone's MS could progress. This could help people to make more informed treatment choices.

How will it help people with MS?

Finding biomarkers and genetic differences that predict MS progression will allow people with MS have greater certainty over their lives. It can also help them make better informed choices when deciding to take more or less aggressive treatment.

The difference you can make

MS is unpredictable and can be hard to live with. Giving people greater certainty about how their condition will progress is one of our top seven organisational goals. But we can only do this with your support.

The next research breakthrough is in reach

Your donation will help stop MS.

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    Our minimum donation is £2, please enter a different amount.

£30could process one blood sample, giving researchers crucial information about genes and the immune system.

£50could pay for an hour on a microscope, so scientists can study cells and tissue in greater detail and improve their understanding of the biology of MS.

£100could pay for half an hour of MRI use, so researchers can monitor the success of clinical trials and understand MS in more detail.

Every penny you give really does take us a step closer to stopping MS. Your donation will make a difference.

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    Our minimum donation is £2, please enter a different amount.

£10a month could pay for lab equipment like microscope slides to study the building blocks of MS

£20a month could pay for lab equipment like petri dishes to grow bacteria important for studying genetics

£30a month could process a blood sample to help us understand what causes MS, so we can stop it in its tracks

Your regular donation means we can keep funding world class MS research with confidence. Together we will stop MS.

MS researcher at work in lab, using a pipette