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Canadian researchers reverse MS-like condition in mice
12 Aug 2009
Scientists at McGill University in Canada have successfully reversed a condition similar to multiple sclerosis (MS) in mice.
Reporting their work this week in the scientific journal Nature Medicine, the researchers discovered a technique that was able to reverse EAE, a condition similar to relapsing remitting MS, in laboratory models.
The researchers found a way to make a specific type of immune cell, called a regulatory B cell, from tissues in the laboratory by treating them with a fusion of molecules, known as a 'fusokine'.
These regulatory B cells were then transplanted into the veins of mice with EAE and monitored for improvement. Researchers found that the treated mice went into complete remission.
Researchers say the technique could potentially be replicated in people with autoimmune conditions such as MS and others such as Crohn's disease and arthritis.
Dr Susan Kohlhaas, Research Communications Officer at the MS Society, said, "This early stage research shows that EAE can be reversed in mice but it’s important to remember that EAE has been treated successfully before and is distinct from MS.
"Determining whether this technique can apply to people with MS is the next challenge."
The researchers found a way to make a specific type of immune cell, called a regulatory B cell, from tissues in the laboratory by treating them with a fusion of molecules, known as a 'fusokine'.
These regulatory B cells were then transplanted into the veins of mice with EAE and monitored for improvement. Researchers found that the treated mice went into complete remission.
Researchers say the technique could potentially be replicated in people with autoimmune conditions such as MS and others such as Crohn's disease and arthritis.
Dr Susan Kohlhaas, Research Communications Officer at the MS Society, said, "This early stage research shows that EAE can be reversed in mice but it’s important to remember that EAE has been treated successfully before and is distinct from MS.
"Determining whether this technique can apply to people with MS is the next challenge."
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